Behavior Health and Wellness Blog

Cognitive effects in midlife of long-term cannabis use

Across the United States, the landscape of cannabis use has shifted dramatically. What was once a tightly restricted substance has now become a booming multibillion-dollar industry, with 37 states legalizing medical cannabis and 19 approving recreational use as of June 2022. Cannabis is recognized for its therapeutic potential—helping with seizures, nausea, and appetite loss—but the products of today differ vastly from those of the past. Modern cannabis often contains THC levels five to ten times higher than in the 1970s, increasing both potency and the potential for dependency. As legalization spreads and public perception softens, scientists are now raising important questions about how long-term, heavy cannabis use may affect the brain, particularly cognition and memory.

Key Facts:

  • Medical cannabis is legal in 37 states; recreational use in 19 (as of June 2022).
  • Modern cannabis contains 15–30% THC—up from 1–4% in the 1970s.
  • Long-term, heavy use (weekly or more) may impair learning, memory, and processing speed.
  • Cognitive decline from cannabis can exceed that caused by alcohol or tobacco.
  • Users showed smaller hippocampi—the brain’s memory center—in research studies.
  • Light, infrequent use did not show measurable cognitive deficits.
  • More studies are needed to clarify cannabis’s long-term effects on brain health.


As cannabis continues to gain mainstream acceptance, it’s crucial to balance enthusiasm with awareness. The potential medical benefits are undeniable, but so are the cognitive risks associated with frequent, high-potency use. Continued research and open dialogue between users, healthcare providers, and policymakers will be key to ensuring safe, informed, and responsible use moving forward.

Reference:https://www.health.harvard.edu/blog/cognitive-effects-of-long-term-cannabis-use-in-midlife-202206142760

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